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Diffusion01:12

Diffusion

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Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Facilitated Transport01:19

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The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In  facilitated transport, also known as facilitated diffusion, molecules and ions travel across a...
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Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
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Dialysis01:15

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Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
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A cantilever beam with a rectangular cross-section under distributed and point loads experiences shearing stresses. The analysis begins by identifying the loads acting on the beam. Then, the reactions at the beam's fixed end are calculated using equilibrium equations. The vertical reaction is a combination of the distributed and point loads, while the moment reaction is the sum of their moments. The shear force distribution along the beam, resulting from these loads, is established by creating...
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Solution to the shearing problem via guided diffusion.

Xin Tang, Keke Liu, Jie Chen

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    |February 20, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Pseudoinverse-guided diffusion models (ΠGDM) offer a novel solution for wavefront reconstruction from lateral shearing interferometry (LSI). This method achieves high-precision metrology from single shearograms, outperforming conventional techniques in fidelity and noise robustness.

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    Area of Science:

    • Optical Metrology
    • Computational Imaging
    • Wavefront Sensing

    Background:

    • Wavefront reconstruction from lateral shearing interferometry (LSI) is an ill-posed inverse problem.
    • Existing methods often require multiple measurements or rely on potentially biased assumptions.
    • Noise sensitivity and information loss are significant challenges in LSI.

    Purpose of the Study:

    • To introduce a novel framework, pseudoinverse-guided diffusion models (ΠGDM), for wavefront reconstruction.
    • To leverage a pre-trained diffusion model as a data-driven prior for improved reconstruction.
    • To address the limitations of conventional LSI techniques by enabling high-fidelity reconstruction from single shearograms.

    Main Methods:

    • Integration of LSI physics using Vector-Jacobian product guidance within a diffusion model framework.
    • Utilizing a pre-trained unconditional diffusion model as a robust prior.
    • Benchmarking against classical Zonal integration, Fourier, Tikhonov regularization, and supervised deep learning methods.

    Main Results:

    • ΠGDM demonstrates superior fidelity and noise robustness compared to benchmark methods in both simulations and experimental validation.
    • The framework successfully recovers missing spatial frequencies while ensuring measurement consistency.
    • Achieves high-precision metrology from single shearograms, a significant improvement over traditional approaches.

    Conclusions:

    • ΠGDM presents a novel and effective approach for wavefront reconstruction in LSI.
    • It offers a versatile, zero-shot alternative to supervised learning methods, eliminating the need for task-specific training.
    • The method enhances metrology precision and robustness, overcoming key challenges in LSI.