Related Experiment Video
Updated: Feb 21, 2026
Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
Published on: March 22, 2022
Integrated ESR and PLT-H Measurement Using the BC-6800 Plus Hematology Analyzer: A Comprehensive Analytical
Meilin Chen1, Jinghai Yan1, Manman Ye1
1Department of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Background:
Complete blood count (CBC) and erythrocyte sedimentation rate (ESR) are essential tests in clinical practice. The Mindray BC-6800 Plus integrates CBC and ESR analysis through its Easy-W ESR module and a hybrid platelet channel (PLT-H) designed to improve platelet quantification, especially under interference.
Methods:
A prospective analytical study was conducted following CLSI guidelines (EP05-A3, EP06-A, EP09c). A total of 460 venous samples were analyzed across multiple modes (Auto, Open-Vial, Predilute). PLT-H was compared with PLT-O and reference values; ESR with the BC-760CS, which shares the same ESR module validated against Westergren. Interference testing included samples with low MCV (< 75 fL) and high MPV (> 10 fL).
Results:
PLT-H background was consistently < 5 × 109/L. Precision met predefined limits (CV ≤ 4% whole blood, ≤ 8% predilute; ESR SD ≤ 2 mm/h at ≤ 20 mm/h, CV ≤ 10% at > 20 mm/h). Carryover was ≤ 0.2%. PLT-H showed excellent linearity to 5000 × 109/L (r = 0.999) and tighter bias distribution than PLT-O. Agreement was strong for ESR between BC-6800 Plus and BC-760CS (r = 0.989) and for PLT-H versus PLT-O (r = 0.992). PLT-H maintained robustness in interference-prone samples (r = 0.992).
Conclusion:
The BC-6800 Plus demonstrated excellent analytical performance for ESR and PLT-H, delivering accurate, reproducible, and interference-resistant results. It supports efficient, high-quality testing in modern laboratories.
