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Functional Roles of Non-Coding RNAs in Graves' Disease
Omid Anbiyaee1, Abdolah Mousavi Salehi2,3, Bahar Jaberian Asl4
1Cardiovascular Research Center, Namazi Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Current Molecular Medicine
|February 20, 2026
Summary
This review explores non-coding RNAs (ncRNAs) in Graves' disease (GD). It highlights their role in GD development, diagnosis, and potential as therapeutic targets for this common thyroid disorder.
Area of Science:
- Endocrinology and Molecular Biology
Background:
- Graves' disease (GD) is the leading cause of hyperthyroidism globally, characterized by thyroid dysfunction, eye abnormalities (Graves' orbitopathy), and skin issues (pretibial myxedema).
- Pathogenesis involves autoantibodies stimulating the thyroid-stimulating hormone receptor (TSHR), leading to excessive thyroid hormone production.
Purpose of the Study:
- To comprehensively review the role of non-coding RNAs (ncRNAs) in the pathogenesis, diagnosis, and treatment of Graves' disease.
- To analyze current research on ncRNAs, including circular RNAs (circRNAs), long noncoding RNAs (lncRNAs), and small non-coding RNAs (sncRNAs), in GD.
Main Methods:
- Literature review focusing on molecular factors, specifically ncRNAs, implicated in Graves' disease.
- Analysis of existing studies detailing the function of various ncRNA classes in cellular regulation relevant to GD.
Main Results:
- NcRNAs are crucial regulators of cellular biology and are increasingly recognized for their involvement in GD.
- Different types of ncRNAs (circRNAs, lncRNAs, sncRNAs) play significant roles in the development and progression of Graves' disease.
Conclusions:
- NcRNAs represent a promising area for understanding and potentially treating Graves' disease.
- Further research into ncRNAs could lead to novel diagnostic markers and therapeutic strategies for GD and its associated conditions.
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