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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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Epigenetics in B-CLL.

Alexandra Chu1, Flavia Soto2, Rodrigo Hurtado2

  • 1The International Circle of Genetic Studies Project New York Chapter, New York City, New York, USA.

International Journal of Genomics
|February 20, 2026
PubMed
Summary
This summary is machine-generated.

Epigenetic alterations, including DNA methylation and microRNAs, are crucial in B-cell chronic lymphocytic leukemia (B-CLL). Analyzing these epigenetic changes helps predict disease progression and patient survival.

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Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • B-cell chronic lymphocytic leukemia (B-CLL) is the most prevalent adult hematological malignancy.
  • B-CLL exhibits diverse clinical behaviors, from indolent to aggressive forms resistant to standard therapies.

Purpose of the Study:

  • To investigate the role of epigenetic alterations in B-CLL prognosis.
  • To establish epigenetic analysis as a key method for understanding B-CLL progression and predicting patient outcomes.

Main Methods:

  • Analysis of epigenetic mechanisms in B-CLL.
  • Focus on DNA methylation, histone modifications, and microRNA regulation.

Main Results:

  • Epigenetic alterations significantly influence B-CLL prognosis.
  • Specific epigenetic changes are linked to disease progression and therapeutic response.

Conclusions:

  • Epigenetic profiling is essential for understanding B-CLL.
  • Epigenetic analysis aids in predicting treatment response and patient survival in B-CLL.