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Related Experiment Video

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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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Acute psilocin increased cortical activity in rat.

Junhong Liu1, Yuanyuan Wang1,2, Ke Xia1

  • 1Stake Key Laboratory of National Security Specially Needed Medicines, Beijing, China.

Frontiers in Neuroscience
|February 20, 2026
PubMed
Summary
This summary is machine-generated.

Psilocin significantly increases brain activity and functional connectivity in rats, mirroring human responses. This heightened neural activation, evidenced by EGR1 gene expression, may explain psilocin

Keywords:
5-HT2ABOLD fMRIdepressionegr1functional connectivitypsilocinpsychedelics

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Neuroimaging

Background:

  • Psilocin, a psychoactive compound from magic mushrooms, has known effects but limited mechanistic understanding.
  • Blood-oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is crucial for studying brain activity changes noninvasively.
  • The impact of psilocin on rat brain activity using fMRI remains underexplored.

Purpose of the Study:

  • To investigate the effects of psilocin on rat brain activity and functional connectivity (FC).
  • To correlate fMRI findings with the expression of EGR1, an immediate early gene linked to depression.

Main Methods:

  • Utilized BOLD fMRI to monitor brain activity in rats following psilocin administration.
  • Performed region-of-interest (ROI)-wise FC analysis and seed-based analyses.
  • Quantified EGR1 expression using immunofluorescence (IF) to assess neural activation.

Main Results:

  • Psilocin injection (2.0 mg/kg) elevated brain activity in cortical, hippocampal, and striatal regions.
  • Enhanced functional connectivity was observed between several brain regions, including the cingulate cortex and striatum.
  • Increased EGR1 levels in cortical and striatal areas correlated with fMRI-detected brain activation.

Conclusions:

  • Psilocin induces a hyperactive brain state in rats, consistent with observed human effects.
  • Increased brain activity, enhanced FC, and EGR1 upregulation likely contribute to psilocin's pharmacological actions.
  • This study provides valuable neuroimaging insights into psilocin's mechanisms of action in a preclinical model.