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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
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Fungal Phylum Microsporidia01:28

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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Fungal Phylum Ascomycota01:28

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Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
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Fungal Phylum Basidiomycota01:26

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Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
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Antifungal Agents01:15

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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Updated: May 2, 2026

The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis
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Disseminated mucormycosis.

Christopher V Radcliffe1, Elizabeth E Tremblay2, Francisco J Machiavello Roman1

  • 1Section of Infectious Diseases, Department of Medicine, Yale School of Medicine, New Haven, CT, USA.

Idcases
|February 20, 2026
PubMed
Summary
This summary is machine-generated.

New skin lesions in stem cell transplant patients require careful evaluation for invasive mucormycosis. Early diagnosis via biopsy and treatment with Amphotericin B, alongside immune reconstitution, are crucial for better outcomes.

Keywords:
Invasive fungal infectionMucormycosisStem cell transplantation

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Hematology

Background:

  • Stem cell transplant recipients are immunocompromised and susceptible to opportunistic infections.
  • Invasive mucormycosis is a rare but life-threatening fungal infection.
  • Cutaneous manifestations can be the initial presentation of invasive mucormycosis.

Purpose of the Study:

  • To highlight the importance of evaluating new skin lesions in stem cell transplant recipients.
  • To emphasize diagnostic and therapeutic strategies for invasive mucormycosis in this population.

Main Methods:

  • Review of clinical presentations and diagnostic approaches for invasive mucormycosis.
  • Discussion of current treatment guidelines and prognostic factors.

Main Results:

  • New skin lesions in stem cell transplant recipients necessitate a comprehensive workup.
  • Tissue biopsy is essential for confirming invasive mucormycosis.
  • Amphotericin B is the recommended first-line empiric antifungal therapy.
  • Successful management hinges on prompt diagnosis, appropriate antifungal treatment, and immune reconstitution.

Conclusions:

  • Vigilance for cutaneous signs of invasive mucormycosis is critical in stem cell transplant patients.
  • Multidisciplinary management involving infectious disease specialists, hematologists, and dermatologists is often required.
  • Optimizing host immunity is a key component of successful mucormycosis treatment.