Research progress on macrophage regulation of atherosclerosis

Area of Science:

• Cardiovascular Biology
• Immunology
• Pathology

Background:

• Cardiovascular diseases (CVDs) are a leading cause of global mortality and disability.
• Atherosclerosis is a primary pathological process underlying CVDs.
• Macrophages are critical cellular players in atherosclerosis initiation, plaque progression, and rupture.

Purpose of the Study:

• To review the mechanisms of macrophage involvement in atherosclerosis.
• To summarize recent therapeutic advances targeting macrophage functions in atherosclerosis treatment and prevention.

Main Methods:

• Literature review of current evidence on macrophage roles in atherosclerosis.
• Synthesis of research on therapeutic strategies targeting macrophages.

Main Results:

• Macrophages contribute significantly to plaque development and instability.
• Understanding macrophage mechanisms offers potential therapeutic targets.

Conclusions:

• Macrophages are central to atherosclerosis pathogenesis.
• Targeting macrophages presents promising avenues for novel atherosclerosis therapies.