An individual with multiple high-risk links uncovered: an epidemiological investigation based on molecular network...

Area of Science:

• Epidemiology
• Molecular Biology
• Public Health

Background:

• Molecular network analysis identified a key HIV cluster in Southwestern China (2018-2023).
• The cluster involved young students and non-student men who have sex with men (MSM).

Purpose of the Study:

• Analyze transmission network characteristics within the key HIV cluster.
• Elucidate potential transmission dynamics to prevent further disease spread.

Main Methods:

• Designated key molecular cluster based on node characteristics and network density.
• Conducted face-to-face epidemiological investigations and sexual partner tracing.
• Utilized HIV-1 pol gene sequencing and molecular network/phylogenetic analyses.

Main Results:

• The key cluster comprised 20 males (9 students, 11 non-student MSM).
• Identified a high-risk sexual partner (H) soliciting unprotected anal sex, who was HIV-positive.
• Molecular analysis confirmed H belonged to the same cluster, linking him to other individuals.

Conclusions:

• Combined molecular and epidemiological data detected an individual with multiple high-risk links, preventing further HIV spread.
• Emphasized improving molecular network monitoring and timely epidemiological investigation for HIV prevention and treatment services.