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Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

626
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
626
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

479
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
479
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

827
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
827
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

300
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
300
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

795
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
795
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

662
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
662

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Related Experiment Video

Updated: Feb 21, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Left Atrial Strain Predicts Cardiac Outcomes in Moderate Aortic Stenosis.

Minjung Bak1, Sang Yoon Lee2, Sung-Ji Park2

  • 1Division of Cardiology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea (M.B.).

Circulation. Cardiovascular Imaging
|February 20, 2026
PubMed
Summary

Left atrial reservoir strain (LARS) is a key predictor of adverse cardiac events in moderate aortic stenosis (AS). Assessing LARS can improve risk stratification and guide management for patients with moderate AS.

Keywords:
aortic valve stenosisdeathheart failureprognosissymptom burden

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Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Imaging

Background:

  • Moderate aortic stenosis (AS) carries significant risks, but prognostic factors and cardiac remodeling markers are not well understood.
  • Identifying reliable predictors is crucial for managing patients with moderate AS.

Purpose of the Study:

  • To evaluate prognostic factors in moderate AS, focusing on left atrial strain.
  • To determine the predictive value of these factors for adverse cardiac events.

Main Methods:

  • Retrospective cohort study of 1125 patients with moderate AS.
  • Assessment of cardiac remodeling using speckle-tracking echocardiography, including left atrial reservoir strain (LARS).

Main Results:

  • LARS was the most sensitive and independent predictor of cardiac death and composite outcomes (cardiac death or heart failure hospitalization).
  • Reduced LARS remained significant even after aortic valve replacement.
  • LARS demonstrated superior predictive performance compared to other remodeling parameters.

Conclusions:

  • Left atrial reservoir strain (LARS) is a sensitive and independent prognostic marker in moderate AS.
  • Regular assessment of LARS can enhance risk stratification and guide clinical management.