Related Experiment Video
Updated: Feb 21, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
[Non-cirrhotic portal hypertension complicated by portal biliopathy]
S V Mikhin1, P V Mozgovoy1, V V Mandrikov1
1Volgograd State Medical University, Volgograd, Russia.
Abstract:
The earliest references to association between mechanical jaundice and non-cirrhotic portal hypertension (NCPH) are by Fraser et al. (1944) and Gibson et al. (1965). The term "portal hypertension biliopathy" was proposed by Dhiman et al. (1999). The incidence of asymptomatic form of portal hypertension biliopathy (PHB) in patients with NCPH ranges from 81% to 100% that is significantly higher compared to patients with hepatic block (0-33%). Symptomatic form of PHB occurs only in 5-33% of patients. Any intervention on biliary tract in patients with PHB may result in significant blood loss due to coagulopathy. Currently, there is no consensus on optimal treatment algorithm for patients with symptomatic PHB. The authors present several patients with PHB complicated by mechanical jaundice and variants for correction of this complication.
Related Concept Videos
Hepatic Portal System
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
Esophageal Varices-I: Introduction
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

