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Hypertriglyceridemia: updates from clinical trials of new agents and real-world registries

Mohamed Haseef1,2, Stephen C H Li3, Tobias Gaitt1,2

  • 1Medical School, University of Western Australia, Perth.

Current Opinion in Endocrinology, Diabetes, and Obesity
|February 20, 2026
PubMed

Insights

Hypertriglyceridemia (HTG) is a risk factor for cardiovascular disease and pancreatitis. Novel RNA-based treatments significantly lower triglycerides and reduce pancreatitis risk, with registries offering valuable real-world data.

Area of Science:

  • Cardiology
  • Endocrinology
  • Genetics

Background:

  • Hypertriglyceridemia (HTG) is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) and acute pancreatitis (AP).
  • Early detection and management of HTG are crucial for preventing severe complications.
  • HTG is frequently associated with other cardiometabolic risk factors like obesity, diabetes, and hepatic steatosis.

Purpose of the Study:

  • To review the etiology and novel treatments for HTG.
  • To discuss recent findings from contemporary HTG registries.
  • To highlight the importance of patient registries in understanding and managing HTG.

Main Methods:

  • Literature review of etiology and novel treatments for HTG.
  • Analysis of recent findings from HTG registries.
  • Examination of data from contemporary clinical trials and international registries.

Main Results:

  • Novel RNA-based therapies demonstrate significant triglyceride reduction and decreased AP incidence.
  • A recent trial showed benefits in patients with triglycerides >500 mg/dL, with mixed effects on lipid profiles.
  • International registries provide valuable real-world data on HTG management and outcomes.

Conclusions:

  • HTG registries offer critical insights into the link between HTG and cardiometabolic disorders.
  • Registry data can guide clinical service planning and the translation of therapeutic trial findings.
  • Harmonizing HTG definitions and improving care for severe HTG and familial chylomicronemia syndrome are necessary.
Abstract

Keywords:
atherosclerotic cardiovascular diseasechylomicronemiahypertriglyceridemiapancreatitisregistries

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