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Changes in Cerebellar Multiunit Activity Associated with Ventrolateral Striatal Injury During Spontaneous Motor

Irais Viveros-Martínez¹, Cristofer Zarate-Calderon¹, Lizbeth Vásquez Celaya¹

¹Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala, Col. Industrial Las Ánimas, Xalapa 91190, Veracruz, Mexico.

Medical Sciences (Basel, Switzerland)

|February 20, 2026

Summary

Parkinsonism research shows the cerebellum adapts to ventrolateral striatum (VLS) injury. The cerebellum recalibrates network gain, maintaining motor function despite early circuit dysfunction.

Keywords:

Crus II Multi-Unit Activity Parkinsonism cerebellum dentate nucleus inferior olive spontaneous behavior ventrolateral striatum

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Area of Science:

Neuroscience
Systems Neuroscience
Motor Control

Background:

Parkinsonism is linked to basal ganglia dysfunction.
The cerebellum plays a key role in motor compensation after circuit destabilization.

Purpose of the Study:

To investigate the electrophysiological dynamics of Multi-Unit Activity (MUA) in the cerebellum and inferior olive after ventrolateral striatum (VLS) lesions.
To model circuit-level perturbation and functional compensation in Parkinsonism.

Main Methods:

Induced bilateral mechanical VLS lesions in Wistar rats.
Chronically recorded MUA in Crus II, dentate nucleus (DN), and inferior olive (IO) over four weeks.
Analyzed MUA during spontaneous behaviors: grooming, locomotion, and rearing.

Main Results:

Crus II and IO showed a transition from hyperexcitability to attenuation.
The dentate nucleus (DN) exhibited sustained hypoactivity.
Motor behaviors remained phenotypically preserved despite neurophysiological changes.

Conclusions:

VLS injury induces rapid reorganization in the striato-cerebellar network.
The cerebellum actively adapts by recalibrating network gain.
Motor performance is maintained through homeostatic gain regulation, masking early dysfunction.