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The relationship between coronary complexity and triglyceride glucose index in stable coronary artery disease

Oguz Kilic1, Damla Yalcinkaya Oner2, Fatma Ozpamuk Karadeniz1

  • 1Cardiology Department, Karamanoglu Mehmetbey University, Karaman Research and Training Hospital, Karaman, Turkey.

Cardiovascular Journal of Africa
|February 20, 2026
PubMed

Insights

The triglyceride glucose (TyG) index is linked to increased coronary artery complexity in patients with stable coronary artery disease (CAD). Higher TyG index values may help predict disease severity and prognosis.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Vascular Biology

Background:

  • Coronary artery disease (CAD) poses a significant health burden, necessitating accurate prognostic tools.
  • Evaluating coronary complexity is crucial for managing stable CAD patients.

Purpose of the Study:

  • To investigate the association between the triglyceride glucose (TyG) index and coronary complexity.
  • To determine if the TyG index can serve as a prognostic marker in stable CAD.

Main Methods:

  • Retrospective analysis of 247 stable CAD patients.
  • Patients categorized into two groups based on SYNTAX score (0 vs. ≥1).
  • Comparison of TyG index levels between the groups and correlation with SYNTAX score.

Main Results:

  • The TyG index was significantly higher in patients with higher coronary complexity (SYNTAX ≥1).
  • A strong positive correlation was found between the TyG index and SYNTAX score (r = 0.303, p < 0.001).

Conclusions:

  • Elevated TyG index is associated with increased complexity of coronary artery lesions.
  • The TyG index shows potential as a tool for assessing prognosis in CAD patients.
Abstract

Keywords:
Triglyceride‐Glucose Indexcoronary artery diseasecoronary complexity assessmentinsulin resistance

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