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Updated: Feb 22, 2026

Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae
Published on: April 18, 2016
Golgi Membrane-Associated Degradation (GOMED), a New Intracellular Proteolysis Mechanism
Shigeomi Shimizu1, Shinya Honda2, Satoru Torii2
1Department of Pathological Cell Biology, Advanced Research Initiative, Institute of Science Tokyo, Chiyoda-ku, Tokyo, Japan. shimizu.pcb@mri.tmd.ac.jp.
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The Golgi apparatus is a crucial organelle that is involved in various cellular processes, including cellular secretion, and is primarily responsible for the modification, sorting, and transport of proteins and lipids. However, recently, we discovered a novel Golgi function, namely, Golgi membrane-associated degradation (GOMED). GOMED is a cellular function in which the trans-Golgi membrane undergoes deformation and becomes spherical, breaking down proteins and lipids that have been internalized. This process is conserved from yeast to mammalian cells. GOMED primarily plays a role in the quality control of hormones, cytokines, and cell membrane receptors that pass through the Golgi apparatus, and is crucial for maintaining the normal function of pancreatic β cell, neurons, and intestinal epithelial cells. Therefore, abnormalities in GOMED can lead to neurodegenerative diseases and inflammatory bowel diseases.
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