Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
Golgi Apparatus01:49

Golgi Apparatus

105.3K
As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
105.3K
Golgi Apparatus01:09

Golgi Apparatus

22.4K
Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
22.4K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.3K
Golgi Matrix Proteins01:12

Golgi Matrix Proteins

2.5K
Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
2.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood-based biomarker discovery through integrative transcriptomic and miRNA network analyses in schizophrenia, major depressive disorder, and bipolar disorder.

Computational biology and chemistry·2026
Same author

From compliance to prediction: Clinical Laboratories as digital infrastructure for health-system quality and safety.

International journal for quality in health care : journal of the International Society for Quality in Health Care·2026
Same author

Oncogenic receptor tyrosine kinase signaling is driven by the Golgi protein GOLPH3 and its interaction with MYO18A.

Science signaling·2026
Same author

Global Research Trends, Hotspots and Collaborative Networks in Brain-Derived Extracellular Vesicles: A Multi-Database Bibliometric Analysis.

Neuroinformatics·2026
Same author

Blockchain in Clinical Chemistry: from Hype to Clinical and Operational Value.

Indian journal of clinical biochemistry : IJCB·2026
Same author

AI, Automation and the Future Role of the Clinical Biochemist: from Analyzer Custodian to Clinical Knowledge Partner.

Indian journal of clinical biochemistry : IJCB·2026
Same journal

Future Directions in Biotechnological and Pharmacological Applications of CAIs.

Sub-cellular biochemistry·2026
Same journal

Industrial and Environmental Applications of Carbonic Anhydrases.

Sub-cellular biochemistry·2026
Same journal

Applications of Carbonic Anhydrase Inhibitors in Arthritis, Neuropathic Pain, Acute Mountain Sickness, and Cerebral Ischemia.

Sub-cellular biochemistry·2026
Same journal

Applications of Carbonic Anhydrase Inhibitors in Neurological Disorders, Mechanisms and Therapeutic Potential.

Sub-cellular biochemistry·2026
Same journal

Carbonic Anhydrase Inhibitors in Oncology.

Sub-cellular biochemistry·2026
Same journal

Therapeutic Applications of Carbonic Anhydrase Inhibitors in Ophthalmology.

Sub-cellular biochemistry·2026
See all related articles

Related Experiment Video

Updated: Feb 22, 2026

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

8.8K

Golgi Drivers of Cancer.

Kyle A Starost1,2, Jagadeeswara R Bommi2, Prasenjit Mitra2

  • 1Medical Scientist Training Program, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Sub-Cellular Biochemistry
|February 20, 2026
PubMed
Summary
This summary is machine-generated.

Unbiased cancer genome analyses reveal Golgi-localized proteins driving oncogenic phenotypes. This review highlights key cancer drivers acting at the Golgi and their functional importance in human cancers.

Keywords:
CancerGOLPH3GolgiHRASMYO18AOncogenePhosphatidylinositol 4-phosphateTransformation

More Related Videos

In Vitro Modeling of Cancerous Neural Invasion: The Dorsal Root Ganglion Model
08:23

In Vitro Modeling of Cancerous Neural Invasion: The Dorsal Root Ganglion Model

Published on: April 12, 2016

10.0K
Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells
09:51

Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells

Published on: June 30, 2023

1.5K

Related Experiment Videos

Last Updated: Feb 22, 2026

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

8.8K
In Vitro Modeling of Cancerous Neural Invasion: The Dorsal Root Ganglion Model
08:23

In Vitro Modeling of Cancerous Neural Invasion: The Dorsal Root Ganglion Model

Published on: April 12, 2016

10.0K
Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells
09:51

Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells

Published on: June 30, 2023

1.5K

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Unbiased analyses of cancer genomes, transcriptomes, and proteomes have identified numerous cancer-driving genes.
  • These studies have illuminated a significant, previously unappreciated role for the Golgi apparatus in promoting oncogenic phenotypes.

Purpose of the Study:

  • To review cancer drivers that localize to and function at the Golgi.
  • To highlight evidence of their functional importance in cancer.
  • To discuss their interactions and proposed mechanisms in promoting oncogenesis.

Main Methods:

  • Literature review of unbiased cancer genomic, transcriptomic, and proteomic analyses.
  • Focus on studies identifying Golgi-localized proteins as cancer drivers.
  • Synthesis of evidence for functional importance, Golgi localization, and oncogenic mechanisms.

Main Results:

  • Identification of specific genes acting as cancer drivers at the Golgi.
  • Evidence supporting the functional significance of these Golgi-based drivers in human cancers.
  • Elucidation of functional interactions and proposed mechanisms of oncogenesis.

Conclusions:

  • The Golgi apparatus is a critical site for cancer driver proteins.
  • Understanding Golgi-centric oncogenic mechanisms offers new therapeutic avenues.
  • Further research into Golgi-based cancer drivers is warranted.