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Complexity or simplicity? A replication analysis of low heart rate as a predictor of TMS response in major depressive

Lena Kozyr1, Irakli Kaloiani1, Masataka Wada1

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, United States.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|February 20, 2026
PubMed
Abstract

No abstract available in PubMed .

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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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