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Functional neural changes linked to depression during the menopause transition and the effects of hormone therapy: A
Erin Bondy1, Kathryn Gibson2, Megan Hynd2
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Abstract:
The menopause transition (MT) is associated with increased risk for developing depression, although the underlying neurobiological mechanisms are not well understood. The current narrative review seeks to integrate functional neuroimaging studies that 1) identify neural changes across the MT, 2) examine depression during the MT, and 3) investigate the influence of menopausal hormone therapy (MHT) on brain function during the MT. We focus on domains that have previously been implicated in depression, including emotion processing, cognitive processing, and reward processing. Following a summary of the existing literature, recommendations for the future are provided to help further our understanding of depression during the MT and inform prevention and treatment efforts.
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