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Magneolign O-S: Five neolignans isolated from Magnolia officinalis Rehd. et Wils with their hepatoprotective
Jingying Sun1, Lingzhi Zhang1, Chuangjun Li1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, State Key Laboratory of Digestive Health, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, PR China.
Abstract:
Five undescribed neolignans (1-5), and three known compounds (6-8) were isolated from the root bark of Magnolia officinalis Rehd. et Wils. Compounds 3 and 4 were obtained as racemates and separated completely using a chiral column. Their structures were elucidated through extensive analyses of 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. The hepatoprotective activities of all isolates were assessed. Results indicated that compounds 1 and 8 exhibited significant hepatoprotective activity in both APAP- and H2O2-induced liver injury models. Further in vitro experiments demonstrated that compound 1 attenuated apoptosis by reducing reactive oxygen species production and modulating the expression of key apoptotic proteins.
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