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Factors Associated with Inpatient COVID-19 Vaccine Uptake for Pregnant and Postpartum People

Emily R Burdette1,2,3, Andrea Pelletier2, Taylor S Freret4,5

  • 1Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, United States.

American Journal of Perinatology
|February 20, 2026
PubMed

Insights

COVID-19 vaccine uptake was low in pregnant and postpartum patients, despite inpatient availability. Factors like general vaccine acceptance and longer hospital stays were linked to vaccination, but inpatient access did not significantly increase overall uptake.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Public Health

Background:

  • Assessing COVID-19 vaccine uptake in peripartum populations is crucial for maternal and infant health.
  • Understanding factors influencing vaccination status among pregnant and postpartum individuals is essential for targeted interventions.
  • Inpatient vaccination services offer a potential avenue to improve vaccine coverage in this demographic.

Purpose of the Study:

  • To evaluate COVID-19 vaccine uptake among pregnant and postpartum patients admitted to academic hospitals.
  • To identify factors associated with vaccination status upon admission and inpatient vaccination.
  • To determine the impact of inpatient vaccination services on overall vaccine uptake in this population.

Main Methods:

  • Retrospective cohort study of antepartum and postpartum patients admitted between April 2021 and July 2022.
  • Classification of patients as 'sufficiently vaccinated' or 'eligible for vaccination' upon admission.
  • Statistical analyses including chi-square, t-tests, Wilcoxon rank sum test, and logistic regression were employed.

Main Results:

  • Vaccination uptake at admission was 38.5% for antepartum and 52.6% for postpartum patients.
  • Inpatient vaccination rates were low: 5.5% for eligible antepartum and 9.2% for eligible postpartum patients.
  • Factors associated with inpatient vaccination included influenza vaccination during pregnancy, length of stay, and specific obstetric conditions.

Conclusions:

  • Despite inpatient vaccination availability, COVID-19 vaccine uptake remained low in the peripartum population.
  • General vaccine acceptance and longer hospital stays were associated with receiving the vaccine during hospitalization.
  • Inpatient vaccine access alone did not significantly increase overall vaccine uptake among these patients.
Abstract

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