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Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
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Deferred Cord Clamping and Weight Difference for Very Preterm Infants.

Mary Quinn1, Anup C Katheria2, Jochen Profit1,3

  • 1Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University, Stanford, California, United States.

American Journal of Perinatology
|February 20, 2026
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Summary
This summary is machine-generated.

Deferred cord clamping (DCC) in very preterm infants is linked to a small but significant increase in initial recorded weight. This practice may improve blood volume and weight gain in premature babies.

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Area of Science:

  • Neonatal Medicine
  • Perinatal Research
  • Pediatric Critical Care

Background:

  • Deferred cord clamping (DCC) is a practice aimed at improving neonatal outcomes.
  • Its effect on initial weight in very preterm infants (<32 weeks gestational age) requires further real-world data.

Purpose of the Study:

  • To determine the association between DCC and first-recorded weight in very preterm infants.
  • To analyze real-world data from a large cohort of neonatal intensive care unit (NICU) admissions.

Main Methods:

  • Retrospective cohort study using data from 138 California hospitals (2016-2023).
  • Included infants between 22 and 31 weeks gestational age, excluding cord milking, delivery room deaths, or missing data.
  • Linear regression analysis adjusted for gestational age and intrauterine growth restriction (IUGR).

Main Results:

  • Analysis included 32,634 very preterm infants.
  • Deferred cord clamping (DCC) was associated with a 24g higher first-recorded weight (95% CI: 18-29g).
  • Mean weight was 1,338g with DCC versus 1,290g without.

Conclusions:

  • A minimum of 30 seconds of DCC is associated with a modest increase in first-recorded weight for very preterm infants.
  • This finding supports previous clinical trial evidence suggesting DCC increases blood volume and weight gain.
  • Real-world data confirms the benefits of DCC in a large, diverse population.