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Related Concept Videos

RNA Structure01:19

RNA Structure

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The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
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The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
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Nucleic Acid Structure01:25

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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Nucleic Acids02:43

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Updated: Feb 22, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

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TAV2b Peptide Derivatives Underwind and Stabilize Double-Stranded RNA upon Binding.

Zainab M Rashid1, Misha Klein1, Thor van Heesch2

  • 1Department of Physics and Astronomy and LaserLaB Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands.

Journal of the American Chemical Society
|February 20, 2026
PubMed
Summary
This summary is machine-generated.

Peptidic double-stranded RNA (dsRNA) binders were investigated using magnetic tweezers. These peptides alter dsRNA mechanics, offering insights for improved therapeutic and diagnostic applications.

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Area of Science:

  • Biophysics
  • Molecular Biology
  • Biochemistry

Background:

  • Double-stranded RNA (dsRNA) is crucial for biological processes and therapeutics.
  • Limitations in dsRNA cellular uptake and stability hinder its application.
  • Peptidic dsRNA binders offer potential solutions but their mechanisms are unclear.

Purpose of the Study:

  • Investigate how TAV2b-derived peptidic dsRNA binders recognize RNA.
  • Determine the impact of these peptides on dsRNA mechanical properties.
  • Inform the design of advanced dsRNA binders for clinical use.

Main Methods:

  • Single-molecule magnetic tweezers.
  • Real-time binding experiments.
  • Mechanistic modeling of peptide-RNA interactions.

Main Results:

  • Peptides underwind and stabilize dsRNA.
  • Wild-type peptide increases contour length and decreases persistence length.
  • Homodimeric peptide condenses dsRNA and forms stable complexes.
  • A two-step equilibrium model explains peptide binding and plectoneme formation.

Conclusions:

  • TAV2b-derived peptides modulate dsRNA mechanics through distinct binding modes.
  • Understanding these interactions is key to developing effective dsRNA therapeutics.
  • The findings provide a framework for designing novel dsRNA-binding agents.