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Treatable traits in children with bronchiectasis

Joséphine Annereau1, Apolline Gonsard2, Rola Abou Taam3

  • 1Department of Paediatric Pulmonology and Allergology, AP-HP, University Hospital Necker-Enfants Malades, F-75015 Paris, France; Université Paris Cité, Inria, Inserm, HeKA, F-75015 Paris, France.

Paediatric Respiratory Reviews
|February 20, 2026
PubMed

Insights

The treatable traits (TT) approach identifies modifiable factors in pediatric bronchiectasis. Further research is needed to support these traits specifically in children.

Area of Science:

  • Pediatric Pulmonology
  • Precision Medicine

Background:

  • Bronchiectasis in children is a complex chronic respiratory condition.
  • Standardized management is crucial, with international guidelines improving consistency.
  • The treatable traits (TT) approach offers a precision-medicine framework.

Purpose of the Study:

  • To identify potential treatable traits (TT) in pediatric bronchiectasis.
  • To assess the evidence base for these TT in children.
  • To guide systematic assessment and future research.

Main Methods:

  • Comprehensive literature review.
  • Identification of potential TT across etiological, pulmonary, extrapulmonary, and behavioral/environmental domains.
  • Assessment of the evidence level for each TT in pediatric populations.

Main Results:

  • Identified 40 potential treatable traits (TT) for pediatric bronchiectasis.
  • Found limited evidence supporting many TT specifically in children.
  • Much of the existing data is extrapolated from adult studies or other respiratory diseases.

Conclusions:

  • The TT approach provides a dynamic framework for individualized assessment in pediatric bronchiectasis.
  • There is an urgent need for pediatric-specific clinical trials to validate these traits.
  • Further research is required to strengthen the evidence base for TT in this population.

Keywords:
BronchiectasisComorbidityMedication adherencePaediatricsPrecision medicineTraits

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