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Updated: May 1, 2026
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Molecular features in gangliogliomas: a systematic review
Benedito Jamilson Araújo Pereira1, Sueli Mieko Oba-Shinjo2, Ivy Karoline Herculano de Azevedo2
1Laboratory of Molecular and Cellular Biology (LIM15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Avenida Dr Arnaldo, 455/4º Andar/Sala 4110, São Paulo, SP, Brazil. benedito.jamilson@hotmail.com.
Purpose:
In the present study, a systematic revision in the Medline was conducted to determine the somatic mutation in gangliogliomas.
Methods:
A Medline search for relevant publications up to October 2024 using the key phrase "ganglioglioma mutation" led to the retrieval of 297 studies. This corpus provided the basis for the present review. The records without abstract or descriptions of somatic mutations were excluded. Only records in the English language were considered.
Results:
A total of 43 papers were evaluated, reporting a total of 1360 cases of ganglioglioma. Among them, 528 cases presented mutations in 6 genes: BRAFV600E, FGFR1, H3K27M, KRAS, IDH1, and RAF1. The most common mutation was BRAFV600E present in 36.94%, followed by the mutation in FGFR1, reported in 1.18% of cases.
Conclusion:
BRAFV600E mutation was the most common alteration observed in gangliogliomas, whereas mutations in other genes, such as FGFR1, H3K27M, KRAS, IDH1, and RAF1, were rare.
