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Published on: July 31, 2017
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Molecular features in gangliogliomas: a systematic review
Benedito Jamilson Araújo Pereira1, Sueli Mieko Oba-Shinjo2, Ivy Karoline Herculano de Azevedo2
1Laboratory of Molecular and Cellular Biology (LIM15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Avenida Dr Arnaldo, 455/4º Andar/Sala 4110, São Paulo, SP, Brazil. benedito.jamilson@hotmail.com.
Summary
The BRAFV600E mutation is the most frequent genetic alteration in gangliogliomas. Other gene mutations, including FGFR1 and KRAS, were found to be rare in this brain tumor type.
Area of Science:
- Neuro-oncology
- Molecular Pathology
- Genetics
Background:
- Gangliogliomas are rare tumors of the central nervous system.
- Understanding the genetic landscape of gangliogliomas is crucial for diagnosis and treatment.
Conclusions:
- BRAFV600E is the predominant somatic mutation in gangliogliomas.
- Mutations in other genes like FGFR1, H3K27M, KRAS, IDH1, and RAF1 are infrequent in this tumor type.
