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Updated: Feb 22, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Photocatalytic Direct Deoxytrifluoromethoxylation of Phenols
Jingya Zhou1, Jia-Yi Li1, Chongjie Su1
1State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China.
Abstract:
We developed a photoredox strategy to achieve the deoxytrifluoromethoxylation of phenols. This approach leverages the propensity of the OCF3 anion to decompose into difluorophosgene, which subsequently reacts in situ with phenol to form an aryl carbonofluoridate, thereby reducing the bond energy of the Csp2-O bond. The use of organic photoredox catalysts enables the operation of this method under mild conditions, with simple procedures and broad applicability to various phenolic substrates, and exhibits excellent selectivity among multiple C-O bonds.
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