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Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

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Published on: October 27, 2014

Practical and translational therapeutic elements for GBM therapy.

Seyedeh Elham Norollahi¹, Ali Najafizadeh², Elahe Bakhshalipour²

¹Reproductive Health Research Center, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran; Medical Biotechnology Research Center, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.

|February 21, 2026

Summary

This summary is machine-generated.

Glioblastoma multiforme is a deadly brain cancer lacking effective treatments. This review explores innovative translational therapies like gene therapy and stem cells for improved glioblastoma diagnosis and treatment.

Keywords:

Aptamer GBM MSCs Translational elements iPSCs

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Area of Science:

Neuro-oncology
Translational Medicine
Biotechnology

Background:

Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor patient survival rates.
Current therapeutic strategies for GBM lack definitive efficacy in treatment and diagnosis.
There is a critical need for novel and effective approaches to combat GBM.

Purpose of the Study:

To review and discuss emerging translational elements for glioblastoma diagnosis and treatment.
To highlight the potential of gene therapy, stem cells, and aptamers in advancing GBM care.
To provide a comprehensive overview of innovative therapeutic strategies for GBM.

Main Methods:

Review of current literature on translational therapies for glioblastoma.
Discussion of gene therapy approaches: suicide gene therapy, tumor suppressor gene therapy, and oncolytic virus therapy.
Exploration of cell-based therapies: mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs).
Examination of nanotechnology (nanoparticles) and molecular probes (aptamers) in GBM detection and therapy.

Main Results:

Translational elements offer promising new avenues for GBM management.
Gene therapy modalities show potential for targeted cancer cell destruction.
Stem cell therapies present opportunities for drug delivery and tumor suppression.
Aptamers provide a novel tool for precise GBM target detection.

Conclusions:

Innovative translational therapies, including gene therapy, stem cells, and aptamers, represent a significant advancement in GBM diagnosis and treatment.
These approaches hold promise for overcoming the limitations of conventional GBM therapies.
Further research and clinical translation are essential to fully realize the potential of these novel strategies for improving patient outcomes in glioblastoma.