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Updated: Feb 23, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Undescribed and nephroprotective diterpenoids from Daphne genkwa
Hong-Bo Ye1, Xian-Run Wu2, Li Wang2
1Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Institute of International Rivers and Eco-security, School of Chemical Science and Technology, Yunnan University, Kunming, 650500, China; Southwest United Graduate School, Kunming 650092, China.
Abstract:
Two previously undescribed lathyrane-type diterpenoids, daphngenoids A-B (1-2), and one new daphnane-type diterpenoid, daphngenoid C (3), along with eight known compounds (4-11), were isolated from the buds of Daphne genkwa. Notably, daphngenoids A-B (1-2) significantly inhibited doxorubicin-induced inflammation and oxidative stress in the human kidney proximal tubular epithelial cell line (HK-2).
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