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Updated: Feb 23, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

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Optimal transport model for gas migration in the intestinal wall

Arturo Tozzi1, Raffaele Minella2

  • 1Center for Nonlinear Science, Department of Physics, University of North Texas, 1155 Union Circle, #311427 Denton, Denton, TX, 76203-5017, USA.

Biochimie
|February 21, 2026
PubMed
Summary

This study models gas movement in pneumatosis intestinalis (PI), revealing early diffusion followed by tissue trapping and microbubble formation. This mathematical approach aids in understanding PI progression and severity.

Keywords:
Computational modelingDiffusion dynamicsEpithelial permeabilityGas kineticsGas retentionIschemic bowelMicrocirculationNumerical simulationPermeability gradientsTissue mechanics

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