Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

663
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
663
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

221
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
221
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

7.1K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
7.1K
Lipid Absorption01:24

Lipid Absorption

3.0K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
3.0K
Variability: Analysis01:11

Variability: Analysis

570
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
570
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

5.9K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic state determines the brain and direct islet effects of liraglutide on enhanced insulin secretion.

Diabetologia·2026
Same author

The Dark Tetrad and academic dishonesty: a systematic review and narrative synthesis of personality predictors of cheating, plagiarism, and deception in education.

BMC psychology·2026
Same author

Serum proteomic atlas reveals distinct molecular signatures of lupus nephritis activity, chronicity, and treatment response.

bioRxiv : the preprint server for biology·2026
Same author

Improving social support among sports medicine practitioners: a call to action.

British journal of sports medicine·2026
Same author

Tackle higher or lower? Simulation to evaluate how changing the tackle height would impact the number of concussions and head acceleration events in men's professional rugby league.

British journal of sports medicine·2026
Same author

Instrumented Mouthguards in Women's Rugby League: Quantifying the Incidence and Probability of Head Acceleration Events at Group and Individual Levels.

Sports medicine (Auckland, N.Z.)·2026
Same journal

Response to letter regarding article, "Apolipoproteins, lipoprotein(a), and conventional markers of dyslipidemia in children with nephrotic syndrome in disease remission".

Journal of clinical lipidology·2026
Same journal

Apolipoprotein B reduction and coronary plaque delipidation: Clarifying treatment dynamics and analytic thresholds.

Journal of clinical lipidology·2026
Same journal

Recurrence of cardiovascular events despite achieving LDL-C <1.4 mmol/L in patients with coronary artery disease.

Journal of clinical lipidology·2026
Same journal

Association of small dense LDL cholesterol and inflammation with plaque rupture in acute coronary syndrome: An OCT study.

Journal of clinical lipidology·2026
Same journal

Effect of incorporating 1 avocado per day on lipoprotein particle concentrations compared to habitual intake in adults with abdominal obesity: An ancillary study of the Habitual Diet and Avocado Trial, a randomized controlled trial.

Journal of clinical lipidology·2026
Same journal

Radiographic measurement of the Achilles tendon for diagnosis of familial hypercholesterolemia.

Journal of clinical lipidology·2026
See all related articles

Related Experiment Video

Updated: Feb 23, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

12.6K

Intraindividual variability in lipoprotein(a).

Lakshmi Lakkineni1, Matthew Waite2, Alessia David3

  • 1Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK (Lakkineni, Waite, Jones, and Cegla).

Journal of Clinical Lipidology
|February 21, 2026
PubMed
Summary
This summary is machine-generated.

Repeat lipoprotein(a) [Lp(a)] testing is usually unnecessary, as intraindividual variation often exceeds lab standards. However, consider repeat Lp(a) tests for patients near risk thresholds or considering Lp(a)-lowering therapies.

Keywords:
Cardiovascular riskCoefficient of variationDyslipidaemiaIntraindividual variationLipoprotein(a)Lp(a)

More Related Videos

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.8K
High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

480

Related Experiment Videos

Last Updated: Feb 23, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

12.6K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.8K
High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

480

Area of Science:

  • Cardiovascular Medicine
  • Clinical Chemistry
  • Laboratory Medicine

Background:

  • Lipoprotein(a) [Lp(a)] is a key independent risk factor for atherosclerotic cardiovascular disease.
  • While Lp(a) levels are generally stable, the extent of intraindividual variation and necessity of repeat testing remain unclear.

Purpose of the Study:

  • To evaluate intraindividual variation in Lp(a) levels.
  • To assess the clinical impact of repeat Lp(a) testing on cardiovascular risk classification.

Main Methods:

  • Retrospective analysis of 250 patients with at least two Lp(a) measurements.
  • Measurements were taken over a mean period of 17.1 ± 15.5 months at a tertiary care lipid clinic.

Main Results:

  • Intraindividual coefficients of variation (CV) for Lp(a) exceeded laboratory standards.
  • Cardiovascular risk reclassification occurred for 12.4% (NLA thresholds) and 6.8% (ESC threshold).
  • Variability was not associated with time between tests, medications, or biochemical parameters.

Conclusions:

  • Repeat Lp(a) testing is generally not necessary.
  • Consider repeat testing for individuals near risk thresholds or those evaluated for Lp(a)-lowering therapies.