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ERCP-based management of pediatric chronic pancreatitis: Results from a retrospective long-term multicentric study

Simona Faraci1, Giovanni Rollo1, Federico Alghisi2

  • 1Gastroenterology and nutrition Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|February 21, 2026
PubMed

Insights

Endoscopic retrograde cholangiopancreatography (ERCP) effectively reduces acute pancreatitis episodes in children with chronic pancreatitis. This procedure may improve their quality of life by decreasing symptom recurrence.

Area of Science:

  • Pediatric Gastroenterology
  • Interventional Endoscopy

Background:

  • Chronic pancreatitis (CP) in children leads to recurrent acute episodes and progressive pancreatic dysfunction.
  • Endoscopic retrograde cholangiopancreatography (ERCP) is utilized for managing ductal issues in CP, but pediatric evidence is scarce.

Purpose of the Study:

  • To evaluate the efficacy and safety of ERCP-based management for pediatric patients with genetically associated CP.
  • To assess the impact of ERCP on pancreatitis recurrence rates in this population.

Main Methods:

  • A multicentric retrospective study included children with genetically associated CP undergoing ERCP.
  • Data on clinical procedures, outcomes, and pancreatitis incidence rates before and after ERCP were collected and compared.

Main Results:

  • Forty-two pediatric patients underwent ERCP, with a mean of 4.5 procedures each.
  • ERCP significantly reduced acute pancreatitis episodes (PIRpre 4.6 vs PIRpost 1.1, p = 0.0024), irrespective of stent placement.
  • Post-ERCP pancreatitis (PEP) occurred in 14.2% of procedures, mostly mild; complications were rare and managed conservatively.

Conclusions:

  • ERCP is a safe and effective treatment for reducing pancreatitis recurrence in children with genetically associated CP.
  • The findings suggest ERCP can potentially enhance the quality of life for these young patients.
Abstract

Keywords:
Pancreatic duct obstructionPediatric pancreatologyTherapeutic ERCP

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