A perfect storm: consequences of excess inhibitory neurotransmission after anaesthesia and surgery

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Updated: Feb 23, 2026

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
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Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

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Beverley A Orser1, Connor T A Brenna2, Hugh C Hemmings3

  • 1Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada; Department of Anesthesiology and Pain Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

British Journal of Anaesthesia
|February 21, 2026
PubMed

Keywords:
GABA(A) receptorsastrocyteshydrogen peroxideperioperative neurocognitive disordersreceptor traffickingtonic inhibition

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