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Plasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay

Michel N Nafash1,2,3, Sarah E Svirsky4, Xuemei Zeng1,2,3

  • 1Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Scientific Reports
|February 21, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Alzheimer’s diseaseAnalytical validationBlood-based biomarkersBrain-derived tauClinical validationTraumatic brain injury

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Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or quantified.