Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

1.7K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.7K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

39
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
39
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.5K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.5K
Allergic Reactions02:06

Allergic Reactions

32.6K
Overview
32.6K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

2.0K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.0K
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

565
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
565

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A practical inflammatory blood-cell marker for cardiovascular risk stratification in psoriasis: Development of the Platelet-Leukocyte Adjusted Cardiovascular (PLAC) score.

PloS one·2026
Same author

GRAPPA 2025 Annual Meeting Report: Session on Geographic Variations in Psoriatic Arthritis/Psoriasis Care and Resource Limitations.

The Journal of rheumatology·2026
Same author

Guselkumab Safety in Patients With Latent Tuberculosis: Analysis of 11 Studies in Psoriatic Disease.

The Journal of dermatology·2026
Same author

Efficacy of Upadacitinib in Patients with Atopic Dermatitis of the Head and Neck Region.

Dermatology and therapy·2026
Same author

Dual site targeting of the bacterial 70S ribosome by tetracyclines.

Nature communications·2026
Same author

Zasocitinib (TAK-279), a Highly Selective Oral TYK2 Inhibitor, Demonstrates Skin Clearance in Patients with Moderate-to-Severe Plaque Psoriasis: Post Hoc Analyses of a Randomized Phase IIb Trial.

Dermatology and therapy·2026

Related Experiment Video

Updated: Feb 24, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.7K

Systemic Corticosteroid Exposure in Patients with Atopic Dermatitis: A US Population-Based Study.

Christopher G Bunick1, Ruth Ann Vleugels2, Mark Lebwohl3

  • 1Department of Dermatology and Program in Translational Biomedicine, Yale School of Medicine, New Haven, CT, USA.

Dermatology and Therapy
|February 22, 2026
PubMed
Summary

Systemic corticosteroids are widely used for atopic dermatitis (AD) in the US, despite guidelines recommending against them. This highlights a need for alternative treatments to reduce steroid reliance.

Keywords:
Claims databaseCohort studyCorticosteroidDermatitis, atopicObservational studyPrevalence

More Related Videos

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.2K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.1K

Related Experiment Videos

Last Updated: Feb 24, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.7K
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.2K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.1K

Area of Science:

  • Dermatology
  • Pharmacology
  • Real-world evidence studies

Background:

  • Clinical guidelines advise against routine systemic corticosteroid use for atopic dermatitis (AD) due to adverse effects.
  • Real-world adherence to these recommendations is not well-understood.

Purpose of the Study:

  • To evaluate the real-world use and adherence to guidelines regarding systemic corticosteroid prescriptions in patients diagnosed with atopic dermatitis (AD).

Main Methods:

  • Retrospective cohort study analyzing US healthcare claims data (Optum Clinformatics Data Mart Database).
  • Two cohorts were established: an exposure cohort (first systemic corticosteroid use post-AD diagnosis) and a diagnosis-based cohort (first AD diagnosis).
  • Patients aged ≥12 years with AD between 2017-2024 and continuous insurance were included, with specific exclusion criteria for other inflammatory diseases or significant medical history.

Main Results:

  • In the exposure cohort (29,994 patients), 67.7% received short-term, 8.5% medium-term, and 23.9% long-term systemic corticosteroid therapy.
  • Oral systemic corticosteroids accounted for 80.0% of prescriptions, while intramuscular formulations comprised 20.0%.
  • The diagnosis-based cohort (80,647 patients) showed a 20.0% prevalence of systemic corticosteroid use within 6 months of AD diagnosis.

Conclusions:

  • Systemic corticosteroids are frequently prescribed for atopic dermatitis (AD) patients in the United States.
  • Current prescribing patterns indicate limited adherence to clinical guidelines recommending against routine use.
  • There is a significant need to promote the adoption of corticosteroid-sparing therapies for managing AD.