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Updated: Jul 15, 2026

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds
Published on: August 16, 2014
Electrospun fibrous membrane with triple synergistic effects for cancer therapy
Xia Li1, Congyan Wu2, Jielong Luo2
1State Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, Southwest University, Chongqing, 400715, China; Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing, 400715, China; College of Textile and Apparel Engineering, Xin Jiang Institute of Light Industry Technology, Xinjiang, 830021, China.
Abstract:
Given the complexity, diversity and heterogeneity of tumors, the combination of multiple treatments likely achieves better therapeutic effect than the sole treatment. Herein, to realize the triple therapeutic effects for tumor, fibrous membrane constituted by silk fibroin (SF), poly (lactic-co-glycolic acid) (PLGA), indocyanine green (ICG) and doxorubicin hydrochloride (DOX) were prepared by electrospinning. With the photothermal and photodynamic effects of loaded ICG, this electrospun SF/PLGA/20ICG/DOX membrane could increase by 43.9 °C in 20 min and generated ROS for apoptosis of tumor cells under near infrared (NIR) irradiation. The loaded chemotherapeutic antitumor drug DOX had controllable release effect based on the photothermal property of SF/PLGA/20ICG/DOX membrane. These triple synergistic antitumor effects could kill HepG2 and B16 cells in vitro and could significantly inhibit tumor growth in vivo. The design of electrospun SF/PLGA/20ICG/DOX membrane with triple synergistic effects provides a novel strategy for cancer therapy, showing great potential for application in local treatment of tumor.
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