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Related Experiment Video

Updated: Jul 2, 2026

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

Experimental models and methods for infected wound modeling with Staphylococcus aureus.

Estela Pérez¹, Guillermo Landa², Isabel Bescós³

¹Department of Animal Pathology, University of Zaragoza, Zaragoza, Spain.

Methods in Cell Biology

|February 22, 2026

Summary

This study presents a new mouse model for infected non-healing wounds, crucial for understanding wound healing pathology and developing new treatments. This research aids in exploring infection

Keywords:

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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

Area of Science:

Wound healing research
Infectious disease modeling
Preclinical research

Background:

Non-healing wounds pose a significant financial burden on healthcare.
Current understanding of wound healing mechanisms relies heavily on animal models.
The role of infection in chronic wounds requires further investigation.

Purpose of the Study:

To develop a comprehensive protocol for generating infected acute or chronic non-healing wounds in a mouse model.
To provide a tool for studying the pathology and persistence of non-healing wounds.
To identify potential therapeutic targets for clinical translation.

Main Methods:

Development of a standardized protocol for wound creation in mice.
Infection of wounds to simulate non-healing conditions.
Utilizing the mouse model for preclinical investigation.

Main Results:

A reproducible protocol for creating infected non-healing wounds in mice was established.
The model allows for the study of pathological mechanisms in wound healing.
The model serves as a platform for testing therapeutic interventions.

Conclusions:

The developed mouse model is a valuable tool for preclinical research on infected non-healing wounds.
This model can facilitate the discovery of novel therapeutic strategies for wound care.
Further research using this model can lead to clinical advancements in treating chronic wounds.