Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

903
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
903
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

852
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
852
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.8K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.8K
Errors occurring during blood pressure monitoring01:25

Errors occurring during blood pressure monitoring

1.6K
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
1.6K
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

43
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
43
Insulin: Biosynthesis, Chemistry, and Preparation01:25

Insulin: Biosynthesis, Chemistry, and Preparation

1.6K
The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diabetes Technologist: Optimal Use of Technology in Everyday Practice.

Journal of diabetes science and technology·2026
Same author

Glucose Monitoring and Control Testing in Patients with Type 1 or Type 2 diabetes.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2026
Same author

Smart Pens: Expectations Regarding Use and Functionality From Health Care Providers.

Journal of diabetes science and technology·2026
Same author

Diabetes Technology Across the Lifespan of People With Diabetes (Ages 2-88 Years): Insights From the dt-Report on Usage Trends Across all Age Groups.

Journal of diabetes science and technology·2026
Same author

Automated Insulin Delivery Systems: Impact on Clinical Practice, Discontinuation, Rejection, and Reasons for Not Managing Well.

Journal of diabetes science and technology·2026
Same author

Attitudes and Barriers Toward Automated Insulin Delivery Systems Among Health Care Providers in Germany: A Network Analysis From the dt-Report.

Journal of diabetes science and technology·2026

Related Experiment Video

Updated: Feb 24, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.4K

Do Insulin Pumps Dispense Unwanted or Incorrect Insulin Doses During a Flight?

Andreas Thomas1, Lutz Heinemann2

  • 1Independent Scientific Consulting, Pirna, Germany.

Journal of Diabetes Science and Technology
|February 22, 2026
PubMed
Summary

Air travel safety for chronic illness patients is crucial. This study investigates if atmospheric pressure changes affect insulin pump delivery accuracy, a vital aspect for diabetes management during flights.

Keywords:
CGM systemsautomated insulin delivery (AID) systemsdiabetes technologyinsulin pumps

More Related Videos

Insulin Injection and Hemolymph Extraction to Measure Insulin Sensitivity in Adult Drosophila melanogaster
05:52

Insulin Injection and Hemolymph Extraction to Measure Insulin Sensitivity in Adult Drosophila melanogaster

Published on: June 30, 2011

20.4K
Assessing Insulin Clearance in Mice via In Situ Liver Perfusion
07:30

Assessing Insulin Clearance in Mice via In Situ Liver Perfusion

Published on: December 13, 2024

835

Related Experiment Videos

Last Updated: Feb 24, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.4K
Insulin Injection and Hemolymph Extraction to Measure Insulin Sensitivity in Adult Drosophila melanogaster
05:52

Insulin Injection and Hemolymph Extraction to Measure Insulin Sensitivity in Adult Drosophila melanogaster

Published on: June 30, 2011

20.4K
Assessing Insulin Clearance in Mice via In Situ Liver Perfusion
07:30

Assessing Insulin Clearance in Mice via In Situ Liver Perfusion

Published on: December 13, 2024

835

Area of Science:

  • Aviation Medicine
  • Biomedical Engineering
  • Endocrinology

Background:

  • Passenger safety during air travel is paramount, especially for individuals with chronic health conditions requiring medication.
  • Atmospheric pressure fluctuations within aircraft cabins raise concerns about the reliability of medical devices like insulin pumps.

Purpose of the Study:

  • To evaluate the impact of simulated flight atmospheric pressure changes on the accuracy of insulin pump delivery.
  • To assess the physical and physiological factors influencing insulin delivery from pumps in real-world flight conditions.

Main Methods:

  • An in vitro study was conducted using a pressure chamber to replicate in-flight atmospheric pressure variations.
  • The study observed the formation of air bubbles in insulin reservoirs and their effect on insulin displacement and delivery.

Main Results:

  • Simulated pressure changes led to the formation of air bubbles within the insulin pump reservoir.
  • These air bubbles displaced insulin, potentially causing an unintended increase in insulin delivery.

Conclusions:

  • In vitro findings suggest a risk of altered insulin delivery due to pressure-induced air bubbles.
  • Further investigation into in vivo conditions is necessary to determine the actual clinical relevance of these findings for patients using insulin pumps during flights.