Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.3K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.3K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

839
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
839

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epilepsy and Employment in Europe: A Systematic Review of Literature.

European journal of neurology·2025
Same author

Explanations for higher-than-expected all-cause mortality from April 2021: A scoping review.

Public health·2024
Same author

Sputum culture contamination and associated characteristics in a diagnostic clinical trial, Papua New Guinea.

Public health action·2024
Same author

Extended-spectrum β-lactamase-producing bacteria from hospital wastewater pipes: isolation, characterization and biofilm control using common disinfectants.

The Journal of hospital infection·2024
Same author

More than just the gene: investigating expression using a non-native plasmid and host and its impact on resistance conferred by β-lactamase OXA-58 isolated from a hospital wastewater microbiome.

Letters in applied microbiology·2024
Same author

Cumulative Effects of Watershed Disturbances and Run-of-river Dams on Mercury Cycling: Case Study and Recommendations for Environmental Managers.

Environmental management·2024

Related Experiment Video

Updated: Feb 24, 2026

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
07:38

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing

Published on: September 13, 2016

8.8K

Radiologic, Histologic and Scanning Electron Microscopic Characterization of the Peritoneal Reflection in Crohn's

L Walsh1,2,3, D Walsh1,2,4, C P Dunne1

  • 1School of Medicine, Education Health Sciences Faculty, University of Limerick, Limerick, Ireland.

Clinical Anatomy (New York, N.Y.)
|February 22, 2026
PubMed
Summary

The peritoneal reflection shows increased inflammation and thickening in Crohn's disease. This study reveals a unique mesothelial signature with looping channels in Crohn's disease patients.

Keywords:
Crohn's diseasechannelsperitoneumreflection

More Related Videos

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
08:02

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

Published on: March 12, 2020

7.2K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.7K

Related Experiment Videos

Last Updated: Feb 24, 2026

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
07:38

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing

Published on: September 13, 2016

8.8K
Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
08:02

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

Published on: March 12, 2020

7.2K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.7K

Area of Science:

  • Gastroenterology
  • Anatomy
  • Pathology

Background:

  • The peritoneal reflection, a unique anatomical structure, offers an accessible site for examining peritoneal changes.
  • Crohn's disease involves inflammation that may affect the peritoneum, but specific changes in the peritoneal reflection are not well understood.

Purpose of the Study:

  • To investigate the multilayered characteristics of the peritoneal reflection in normal individuals and in patients with Crohn's disease.
  • To identify specific anatomical and cellular alterations in the peritoneal reflection associated with Crohn's disease.

Main Methods:

  • Digital reconstruction of the peritoneal reflection using computed tomographic (CT) imaging in 20 normal subjects and 20 Crohn's disease patients.
  • Histological and scanning electron microscopy (SEM) analysis of peritoneal reflection samples from 10 normal cadavers and 10 Crohn's disease patients.

Main Results:

  • CT imaging showed increased pixel density in the peritoneal reflection of Crohn's disease patients compared to controls.
  • Histological analysis revealed a significantly thicker peritoneal reflection in Crohn's disease, with increased cellularity and vascularity.
  • SEM identified acute inflammatory infiltrates and a distinctive mesothelial 'signature' of looping channels in Crohn's disease, absent in controls.

Conclusions:

  • The peritoneal reflection is an active site of acute inflammation in Crohn's disease.
  • Crohn's disease is associated with a unique mesothelial signature characterized by a network of looping channels within the peritoneal reflection.