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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
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31-Gene expression profiling for cutaneous melanoma: an expert consensus panel.

Joshua Burshtein1, Clay Cockerell2, David Cotter3

  • 1Department of Dermatology, University of Illinois-Chicago, Chicago, IL, USA.

Dermatology Online Journal
|February 23, 2026
PubMed
Summary

The 31-gene expression profiling (31-GEP) test offers strong prognostic value for invasive melanoma. This test improves melanoma prognosis assessment, even when traditional factors are unknown, supporting its use as a best practice.

Keywords:
31-gene expression profilingclinical utilitymelanomaprognosisrisk stratificationsentinel lymph node biopsy

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Area of Science:

  • Oncology
  • Dermatology
  • Genomics

Background:

  • Invasive melanoma prognosis relies on traditional factors like tumor thickness.
  • Accurate prognostic tools are crucial for effective melanoma management.
  • The 31-gene expression profiling (31-GEP) test has emerged as a potential prognostic biomarker.

Purpose of the Study:

  • To review and synthesize published literature on the clinical efficacy, use, and accuracy of the 31-GEP test for invasive melanoma.
  • To establish consensus-based recommendations for the application of 31-GEP testing in melanoma patient management.

Main Methods:

  • A comprehensive literature search was conducted using specific keywords related to 31-GEP testing and melanoma prognosis.
  • A panel of 10 expert dermatologists reviewed selected articles and developed consensus statements.
  • A modified Delphi process with real-time voting and strength of recommendation assignment was employed to approve statements.

Main Results:

  • Out of 150 articles identified, 26 met the inclusion criteria for the review.
  • The expert panel unanimously adopted 9 consensus statements and recommendations for 31-GEP testing.
  • Eight recommendations received strength 'A' and one received strength 'C'.

Conclusions:

  • There is strong evidence supporting the use of 31-GEP testing for prognostic information in invasive melanoma.
  • The 31-GEP test enhances prognostic accuracy, particularly when traditional factors are indeterminate or when combined with AJCC staging.
  • The test is associated with improved melanoma-specific mortality and overall survival, supporting its role as a best practice.