Related Experiment Video
Updated: Feb 24, 2026
07:50
Location, Dissection, and Analysis of the Murine Stellate Ganglion
Published on: December 22, 2020
13.0K
Distinct Subdivisions of the Cingulo-Insular Region and Their Role in Modulating the Cardiac
Yingxuan Li1,2, Na Clara Pan1,2, Cuiping Xu3,4
1Department of Neurology (Y.L., N.C.P., Y.W.), Xuanwu Hospital, Beijing, China.
Circulation. Arrhythmia and Electrophysiology
|February 23, 2026
Summary
The anterior cingulate gyrus promotes parasympathetic activity, while the posterior insula enhances sympathetic activity, revealing distinct roles in cardio-autonomic balance. These findings offer insights into neurological disorders affecting heart function.
Area of Science:
- Neuroscience
- Cardiology
- Autonomic Nervous System Research
Background:
- The cingulo-insular region is vital for regulating heart activity.
- Specific roles of its subdivisions in sympathetic-parasympathetic balance are not well understood.
Purpose of the Study:
- To investigate the distinct contributions of cingulo-insular subdivisions to cardio-autonomic balance modulation.
- To clarify the neural mechanisms underlying heart rate regulation.
Main Methods:
- Prospective observational study involving patients with drug-resistant epilepsy undergoing stereo-electroencephalography (SEEG) and electrical cortical stimulation.
- Synchronous SEEG and ECG recording during stimulation of the cingulo-insular region.
- Heart rate variability and R-R interval analyses to assess cardiac autonomic balance; correlation of SEEG phase-amplitude coupling with heart rate variability.
Main Results:
- Stimulation of the anterior cingulate gyrus (ACG) enhanced parasympathetic activity, with left ACG increasing pNN50 and right ACG increasing SDNN and SD2.
- Stimulation of the posterior insula (PI) reduced parasympathetic activity; left PI decreased the SD1/SD2 ratio, and right PI decreased high-frequency power and approximate entropy.
- ACG stimulation correlated with increased local phase-amplitude coupling strength.
Conclusions:
- The anterior cingulate gyrus is associated with cardio-parasympathetic dominance.
- The posterior insula is linked to cardio-sympathetic dominance.
- Findings enhance understanding of neural modulation of cardio-autonomic balance, with potential implications for treating autonomic dysfunction in neurological disorders.
More Related Videos
06:40Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
Published on: May 22, 2018
11.3K
10:44Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing
Published on: March 23, 2022
5.0K
Related Concept Videos
01:19Sympathetic Division of the ANS
3.8K
The sympathetic division of the autonomic nervous system (ANS) plays a crucial role in preparing the body for stress, physical activity, and increased energy demands. This division activates the "fight-or-flight" response, enabling individuals to respond effectively to challenging situations.
Originating in the thoracic and lumbar spinal cord segments, the preganglionic fibers of the sympathetic division exit the spinal cord through the white ramus communicans. They then enter the...
Originating in the thoracic and lumbar spinal cord segments, the preganglionic fibers of the sympathetic division exit the spinal cord through the white ramus communicans. They then enter the...
3.8K
01:08Parasympathetic Division of the ANS
4.0K
The parasympathetic division of the autonomic nervous system (ANS) regulates rest and digestion functions in the body. It works in opposition to the sympathetic division, promoting relaxation, conservation of energy, and digestion. The parasympathetic division consists of preganglionic fibers originating from specific cranial nerves (III, VII, IX, X) and the sacral spinal nerves (S2-S4). These fibers synapse with postganglionic neurons in the terminal ganglia, innervating various organs and...
4.0K
01:24Peripheral Nervous System: Ganglia and Nerves
6.2K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
6.2K
01:27Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
3.1K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
3.1K
01:26Autonomic Nervous System: Overview
7.8K
The human nervous system is divided into two main parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and spinal cord, while the PNS contains nerve cells, clusters of nerve cells, and the sensory receptors that are outside the CNS. The PNS has two types of nerve cells: sensory (afferent) and motor (efferent). Sensory cells send signals to the CNS from receptors, and motor cells carry signals from the CNS to organs, muscles, and...
7.8K
01:20Sympathetic Pathways: Sympathetic Chain Ganglia
6.6K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
6.6K