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Dysrhythmia due to Verapamil Overdose in a Young Woman
Abdollah Malakian1, Ensiyeh Taghizadeh1, Zakaria Zakariaei2
1Department of Emergency Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, mazums.ac.ir.
Abstract:
Verapamil (VER) is characterized as a calcium channel blocker (CCB) that can be intentionally or unintentionally overdosed. This drug, like other CCBs, inhibits the entry of calcium into vascular and myocardial tissues through L-type channels. VER exerts negative inotropic and chronotropic effects on the myocardium through antagonistic L-type calcium channels, and an overdose of this drug can result in a decrease in cardiac output, hypotension, and shock. In this report, we describe a unique case of VER toxicity in a 30-year-old woman who experienced a dysrhythmia and heart block after intentionally ingesting 800 mg of sustained-release VER tablets.
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