Related Experiment Video

Updated: Feb 24, 2026

In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
11:16

In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging

Published on: February 25, 2022

3.9K

Predictors of aortic regurgitation and dilatation in children with bicuspid aortic valve

Nilüfer Çetiner Çine1, Ayse Inci Yildirim1, Sinem Altunyuva Usta1

  • 1Department of Pediatric Cardiology, Health Science University Kosuyolu High Specialization Training and Research Hospital, Istanbul, Turkey.

Annals of Pediatric Cardiology
|February 23, 2026
PubMed

Insights

Bicuspid aortic valve patients with right-noncoronary cusp fusion face higher risks of aortic aneurysm and regurgitation. Close monitoring and early preventive treatment are crucial for managing these bicuspid aortic valve complications.

Area of Science:

  • Cardiovascular Medicine
  • Medical Imaging
  • Genetics

Background:

  • Bicuspid aortic valve is a common congenital heart defect associated with aortic root and ascending aorta dilatations.
  • Aortic regurgitation (AR) and aortic dilatation are significant causes of morbidity and mortality in these patients.
  • Understanding the factors influencing AR and dilatation is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the impact of valve morphology, aortic shape, ventricular function, aortic measurements, and serum pro-B-type natriuretic peptide (BNP) levels on AR and dilatation in bicuspid aortic valve patients.
  • To identify specific valve morphologies and aortic shapes associated with increased risk of AR and aortic dilatation.
  • To evaluate the utility of serum pro-BNP levels as a potential biomarker.

Main Methods:

  • A cohort of 126 patients with bicuspid aortic valve was studied, categorized by AR severity.
  • Demographic, clinical, echocardiographic, and serum pro-BNP data were collected.
  • Analysis included valve morphology, aortic structure diameters (root, ascending, descending aorta), ventricular function, and pro-BNP levels.

Main Results:

  • Cusp fusion was the most common valve morphology (71.4%). Patients with cusp fusion had a higher incidence of moderate AR than those with pure bicuspid valves (P=0.022).
  • Significant differences in aortic z-scores (arch, isthmus, descending aorta) were observed between valve shapes, with right-noncoronary cusp fusion showing higher z-scores (P=0.005-0.047).
  • The tubular aortic phenotype group exhibited higher mean age and left ventricular diastolic diameter z-scores (P=0.007-0.037).

Conclusions:

  • Patients with right-noncoronary cusp fusion are at increased risk for aortic aneurysm and AR.
  • Close monitoring and early preventive treatment are recommended for patients with right-noncoronary cusp fusion.
  • Specific valve morphologies and aortic shapes are associated with distinct patterns of aortic dilatation and AR in bicuspid aortic valve disease.
Abstract

Keywords:
Aortic regurgitationaortic root dilatationbicuspid aortic valvechildren

More Related Videos

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

1.7K
Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse08:12

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse

Published on: August 30, 2022

2.4K

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
649
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
828
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
499
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
354
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
678
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
590