Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

18.7K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.7K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

18.8K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Old drugs, new lifelines: An update on drug repurposing against multidrug-resistant Acinetobacter baumannii.

Journal of infection and public health·2026
Same author

Dissecting Uricase Immunogenicity: Unveiling the Role of Quaternary Epitopes through In Silico Analysis : Quaternary Epitope Insights in Uricase Immunogenicity.

Galen medical journal·2026
Same author

Design of a novel proteome-derived scaffold presenting epitopes of Pseudomonas aeruginosa in native conformation.

Scientific reports·2026
Same author

Cellular and molecular landscape of early hidradenitis suppurativa lesions reveals early immune microenvironment.

The Journal of investigative dermatology·2026
Same author

Harnessing epitope reciprocity and multimeric epitope density for a novel multiepitope vaccine design against Acinetobacter baumannii.

Scientific reports·2026
Same author

Corrigendum to "Exosomes as novel tools for renal cell carcinoma therapy, diagnosis, and prognosis" [Heliyon Volume 10, Issue 12, June 30, 2024, Article e32875].

Heliyon·2025
Same journal

Nucleo-amino acid derived AMO as a potential JAK inhibitor: machine learning screening, docking, molecular dynamics, ADMET/toxicity, and MM-PBSA analysis.

Current research in structural biology·2026
Same journal

Shining light on the dark proteome with unstructural biology.

Current research in structural biology·2026
Same journal

Lysozyme revisited: evaluating models of a reference protein in structural biology.

Current research in structural biology·2026
Same journal

Crystal structure of 3-hydroxypropionyl-CoA synthetase (ADP-forming) from <i>Nitrosopumilus maritimus</i>.

Current research in structural biology·2026
Same journal

Ligand-specific conformational dynamics and interaction landscapes of hnRNPA2B1 reveal a structural basis for its functional regulation.

Current research in structural biology·2026
Same journal

Computational hybrid framework integrating clinical-mutation profiling and physics-based simulations to predict structural tolerance of Bruton tyrosine kinase (BTK) and sustained ARQ 531 binding.

Current research in structural biology·2026
See all related articles

Related Experiment Video

Updated: Feb 24, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
09:22

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

6.0K

Decoding the impact of nsSNP variants on BCL6 function through integrated computational analysis.

Shaden M H Mubarak1, Pardis Abdali Dehdezi2, Amir Razavinia3

  • 1Department of Clinical Laboratory Science, Faculty of Pharmacy, University of Kufa, Najaf, Iraq.

Current Research in Structural Biology
|February 23, 2026
PubMed
Summary
This summary is machine-generated.

Non-synonymous single nucleotide polymorphisms (nsSNPs) in BCL6 can impair its function by reducing stability and corepressor binding. These findings may explain clinical variations and guide personalized BCL6-targeted therapies.

Keywords:
BCL6CorepressorsDLBCLDockingMD simulationsnsSNPs

More Related Videos

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.6K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.6K

Related Experiment Videos

Last Updated: Feb 24, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
09:22

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

6.0K
Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.6K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.6K

Area of Science:

  • Genomics
  • Structural Biology
  • Bioinformatics

Background:

  • BCL6 is crucial in cellular processes and diffuse large B-cell lymphoma.
  • BCL6 functions via its BTB domain binding to corepressors.
  • Understanding nsSNP effects on the BCL6 BTB domain is vital.

Purpose of the Study:

  • To analyze structural consequences of deleterious BCL6 nsSNPs on BTB domain function.
  • To investigate the impact of specific nsSNPs on BCL6-corepressor interactions.

Main Methods:

  • Selection and modeling of deleterious BCL6 nsSNPs.
  • Physicochemical, stability, and molecular docking analyses with BCoR, NCoR, SMRT.
  • Molecular Dynamics (MD) simulations of docked complexes.

Main Results:

  • Filtered 54 nsSNPs down to Q113K, V105G, I78T, and I60T mutations.
  • Mutations generally reduced binding affinity to corepressors.
  • MD simulations revealed decreased stability of mutated BCL6 forms.

Conclusions:

  • Selected nsSNPs impair BCL6 transcriptional repression by reducing stability and corepressor binding.
  • Findings may explain clinical differences and aid personalized therapeutic design.
  • Computational results suggest future experimental validation.