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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
A Machine-Assisted Framework for Ontology Development and Standardization: Case Study in Digital Health Technologies.
Fang Chen1, Taylor B Harrison1,2, Sunyang Fu1
1McWilliams School of Biomedical Informatics, University of Texas Health Science Center, Houston, TX, USA.
Digital health technologies (DHTs) offer personalized care but generate vast literature. An adaptive ontology framework, using large language models, offers a semi-automatic solution for organizing and enhancing DHT knowledge.
Area of Science:
- Digital Health
- Medical Informatics
- Knowledge Management
Background:
- Digital health technologies (DHTs) are transforming healthcare delivery and research.
- The rapid growth of DHT literature presents significant challenges for knowledge organization and retrieval.
- Existing ontology development methods in digital health are often manual, hindering efficiency and scalability.
Purpose of the Study:
- To propose and illustrate a novel framework for managing the expanding body of digital health knowledge.
- To address the limitations of traditional, manual ontology development in the digital health domain.
- To introduce the concept of an "adaptive ontology" for systematic and semi-automatic enhancement of DHT ontologies.
Main Methods:
- Developing a framework that integrates DHT lexicon extraction, ontology enrichment, and human-in-the-loop validation.
- Utilizing large language models (LLMs) to power the adaptive ontology concept.
- Applying the framework to systematically classify and enhance digital health ontologies.
Main Results:
- Demonstration of a semi-automatic approach for classifying and enhancing DHT ontologies.
- Successful implementation of an adaptive ontology powered by LLMs.
- A practical method for managing the complexities of evolving digital health information.
Conclusions:
- The proposed adaptive ontology framework offers an efficient and scalable solution for organizing digital health knowledge.
- LLM-powered adaptive ontologies can systematically enhance the management of DHT information.
- This approach provides a viable path for navigating the dynamic landscape of digital health research and application.
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