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Significant Activity of Pytren-2Q, a 2‑Quinoline Polyamine Compound, against High-Concern Human Pathogenic Fungi

Mario Inclán1,2, Maria Paz Clares1, Eduardo Álvarez-Duarte3

  • 1Molecular Science Institute, Universitat de València, C/Catedrático José Beltrán 2, 46980 Paterna, Spain.

ACS Omega
|February 23, 2026
PubMed

Insights

New antifungal compounds are crucial due to rising invasive fungal diseases and resistance. A novel compound, Pytren-2Q, shows potent activity against priority fungal pathogens, including azole-resistant Aspergillus fumigatus, suggesting therapeutic potential.

Area of Science:

  • Medical Mycology
  • Medicinal Chemistry
  • Drug Discovery

Background:

  • Invasive fungal diseases (IFDs) are a growing global health threat.
  • Antifungal drug resistance is increasing, necessitating new therapeutic agents.
  • The World Health Organization (WHO) identified 19 priority fungal pathogens.

Purpose of the Study:

  • To evaluate the in vitro antifungal activity of novel polyamine derivatives.
  • To identify promising candidates for new antifungal drug development.
  • To assess compounds against WHO priority fungal pathogens.

Main Methods:

  • Synthesized 24 polyamine derivatives.
  • Tested in vitro susceptibility of 23 fungal pathogens, including 13 WHO priority species.
  • Evaluated activity against wild-type and azole-resistant Aspergillus fumigatus.

Main Results:

  • A compound, Pytren-2Q (2-quinoline linked to a pyridinophane macrocycle), demonstrated strong in vitro antifungal activity.
  • Pytren-2Q was particularly effective against pathogenic molds.
  • High activity was observed against azole-resistant Aspergillus fumigatus strains.

Conclusions:

  • Pytren-2Q exhibits significant potential as a novel antifungal agent.
  • Its low toxicity, water solubility, and ease of production support further investigation.
  • Pytren-2Q warrants future research for therapeutic validation against critical fungal infections.

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