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Updated: Jun 20, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
Structural-Functional Customization of Nanoscale Liposome-in-Liposome Systems: Precision Engineering Methodology and
Liutao Hu1, Jianfeng Cai2, Chao Lu1,2
1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China.
None:
Liposome-in-liposome systems with multicompartment structures offer advantages in structural complexity and functional programmability, but their application is limited by poor controllability in conventional fabrication. A recent Nature Chemistry study by Elani et al. reports a methodology to prepare sub-200-nm dual-layered liposomes, enabling customizable bilayers and adjustable interbilayer spaces. Their stepwise assembly approach promises to facilitate the integration of artificial intelligence expertise from unilamellar liposome research into liposome-in-liposome systems, thereby further optimizing formulations and enabling biological predictions. Consequently, this advancement may accelerate the clinical translation of liposomal drugs and advance frontier research in areas such as artificial organelles and lipid nanoparticles.
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