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Interoception Network In The Rat Brain.

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Interoception Network In The Rat Brain.

Related Experiment Video

Single-unit In vivo Recordings from the Optic Chiasm of Rat

Single-unit In vivo Recordings from the Optic Chiasm of Rat

Published on: April 2, 2010

Interoception Network in the Rat Brain.

Fatimah M Alkaabi^1,2, Xiaokai Wang¹, Zhongming Liu^1,3

¹Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Biorxiv : the Preprint Server for Biology

|February 23, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

The brain

Keywords:

Brain-Body Interaction Functional Connectivity Interoception Resting State fMRI

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Area of Science:

Neuroscience
Physiology
Systems Biology

Background:

The brain continuously interacts with visceral organs, a process called interoception.
Neural pathways involved in interoception include the nucleus of the solitary tract, hypothalamus, insular cortex, and anterior cingulate cortex.
The influence of interoceptive signaling on resting-state brain activity remains largely unknown.

Purpose of the Study:

To investigate how interoceptive signaling affects resting-state functional connectivity in the brain.
To determine the role of the digestive state and vagus nerve integrity in interoception-related brain activity.

Main Methods:

Resting-state functional magnetic resonance imaging (fMRI) was used in 34 anesthetized rats.
Functional connectivity was analyzed and correlated with the animals' fed or fasted state.

The impact of bilateral cervical vagotomy on functional connectivity was assessed.

Main Results:

A cohesive interoception network was identified, showing reciprocal functional connectivity.
Functional connectivity within this network was stronger in the fed state compared to the fasted state.
Vagal nerve integrity was crucial for maintaining functional connectivity within the interoception network; vagotomy significantly reduced it.

Conclusions:

Resting-state functional connectivity depends on interoceptive signals transmitted via peripheral nerves.
The brain-body interaction, specifically gastrointestinal interoception, actively shapes intrinsic brain activity.
The vagus nerve plays a critical role in mediating these brain-gut interactions during rest.