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Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Related Experiment Video

Updated: Jun 19, 2026

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
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ROS-responsive hydrogel patch orchestrating macrophage reprogramming and mitochondrial protection for post-MI repair.

Minying Li1,2, Qinghe Wu3,4, Weipeng Sun5

  • 1State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.

Bioactive Materials
|February 23, 2026
PubMed
Summary
This summary is machine-generated.

This study developed a novel hydrogel patch delivering salvianolic acid B (DB) to repair heart damage after myocardial infarction (MI). The patch releases DB in response to oxidative stress, improving cardiac function and reducing fibrosis.

Keywords:
Cardiac tissue regenerationLiposomal drug deliveryMyocardial infarction repairROS-Responsive hydrogel patchSalvianolic acid B

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Research
  • Pharmacology

Background:

  • Myocardial infarction (MI) causes irreversible heart damage, leading to heart failure.
  • Salvianolic acid B (DB) shows therapeutic potential for MI but suffers from poor bioavailability.
  • Current treatments for MI have limitations in addressing cardiac remodeling and functional recovery.

Purpose of the Study:

  • To develop an injectable, ROS-responsive hydrogel patch for localized delivery of salvianolic acid B (DB) to repair myocardial infarction (MI) damage.
  • To overcome the bioavailability limitations of DB for effective MI treatment.
  • To establish a rational design strategy for responsive drug delivery systems in cardiac repair.

Main Methods:

  • Network pharmacology analysis identified DB as a potential MI therapeutic.
  • Developed a hydrogel patch using whey protein isolate methacrylate (WPI-MA) and hyaluronic acid (HA-NB).
  • Encapsulated DB in ROS-sensitive liposomes within the hydrogel for targeted release in the oxidative MI microenvironment.
  • Evaluated hydrogel properties (mechanical strength, adhesiveness, antioxidant capacity) *in vitro* and therapeutic efficacy in a murine MI model.

Main Results:

  • The hydrogel patch demonstrated biocompatibility, mechanical strength, myocardial adhesiveness, and sustained antioxidant capacity *in vitro*.
  • In a murine MI model, the hydrogel patch significantly attenuated cardiac fibrosis.
  • The treatment promoted angiogenesis and restored cardiac function post-MI.

Conclusions:

  • The developed ROS-responsive hydrogel patch is a promising system for localized and sustained drug delivery for post-infarction cardiac repair.
  • This approach integrates network pharmacology-based drug discovery with advanced biomaterial design for effective therapeutic outcomes.
  • The study provides a viable strategy for overcoming drug bioavailability issues and enhancing cardiac repair after MI.