Dual-Modality Therapy: Synergistic Enhancement of Radio-Hyperthermia by Gold-Gold Sulfide Nanoparticles in MCF-7
Mahdi Sadat-Darbandi1, Amirhossein Fathabadi2,3, Shabnam Oloomi4
1Department of Medical Physics, Reza Radiotherapy and Oncology Center, Mashhad, Iran.
Background:
This study examines the synergistic impact of Gold-Gold Sulfide (GGS) nanoparticles combined with hyperthermia and radiotherapy on MCF-7 cancer cells. GGS nanoparticles, with strong near-infrared absorption and photothermal properties, enhance cellular sensitivity to radiotherapy.
Methods:
MCF-7 cells were treated with varying GGS concentrations and exposed to radiation doses of 50, 100, and 200 cGy, alongside laser irradiation for 10, 40, and 80 s. The IC50 for GGS nanoparticles was approximately 350 μM.
Results:
Results revealed a significant reduction in cell viability with the combined GGS and laser exposure (p<0.001), demonstrating a synergistic effect in a dose-dependent manner. Further enhancement in cell viability reduction was observed when GGS nanoparticles were combined with both hyperthermia and radiotherapy (p<0.01).
Conclusion:
These findings suggest that GGS nanoparticles offer greater efficacy and reduced toxicity compared to gold nanoparticles, highlighting their potential for improving cancer therapy outcomes through combined hyperthermic and radiotherapeutic approaches.
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