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Deficient de-S-acylation in aging and CLN1 contributes to lyso-mitochondrial dysfunction, lipid dyshomeostasis, and

Sofia Massaro Tieze1,2, Alexander Esqueda1,2, Rachel McAllister3

  • 1Departments of Neurology & Neuroscience, Yale University, New Haven, CT, USA.

Research Square
|February 23, 2026
PubMed

Keywords:
CLN1LipofuscinNeuronal Ceroid LipofuscinosisS-acylationagingautofluorescencelipid homeostasislysosomal storage disordermitochondria-lysosome axisneurodegenerationpalmitoyl protein thioesterase 1

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