Related Experiment Video
Updated: Feb 24, 2026

Extraction of Histones from Clinical Specimens for Epigenetic Profiling by Mass Spectrometry
Published on: November 21, 2025
The role of epigenetic modifications in hematological cancers
Jovana Ilic1, Anna Bold1, Stefan Knop1
1Department of Hematology and Medical Oncology, Paracelsus Medical University, Nuremberg, Germany.
Abstract:
Epigenetic regulation of gene expression entails DNA methylation and histone modifications, which orchestrate chromatin structure and transcriptional activity. Aberrant regulation of these mechanisms contributes to the development and progression of hematological cancers. Mutations in enzymes mediating DNA methylation and histone modification patterns reshape chromatin structure, influencing transcriptional profiles, thus promoting oncogenesis, clonal evolution and drug resistance. This review focuses on significant alterations in DNA methylation patterns, mutations and changes in expression of histone modifying enzymes and chromatin remodeling complexes described in leukemias, lymphomas and multiple myeloma. We summarize the most prominent changes in epigenetic mediators and their impact on transcriptional activity and oncogenesis.
More Related Videos
10:41An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
13:47Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
Published on: February 24, 2015
Related Concept Videos
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Histone Modification
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Histone Modification
Regulation of Hematopoietic Stem Cells