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New-Onset Tic Disorder Associated With Bupropion XL: A Rare Case.

Ovais Rashid1,2,3, Priyanka Hooda1, Simranjeet Kaur1

  • 1Centre of Excellence in Mental Health, Psychiatry, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. RML Hospital, New Delhi, IND.

Cureus
|February 23, 2026
PubMed
Summary

Bupropion XL, a norepinephrine-dopamine reuptake inhibitor (NDRI), can rarely cause new-onset tics. This case report details a patient who developed motor and vocal tics after starting bupropion, which resolved upon discontinuation.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Tics are sudden, rapid, non-rhythmic movements or vocalizations.
Keywords:
adverse drug reactionbupropiondepressionnorepinephrine-dopamine reuptake inhibitor (ndri)tic

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  • Bupropion XL (a norepinephrine-dopamine reuptake inhibitor) is approved for depression and smoking cessation.
  • Tics are rare adverse effects of bupropion, unlike with stimulants or SSRIs.